When nothing else works.

Spravato is an FDA-approved care for adults whose depression hasn’t improved with standard treatments.

Are you feeling stuck with depression?

Some people try several antidepressants and still don’t feel relief. SPRAVATO® (esketamine) is a nasal-spray medication explicitly designed for treatment-resistant depression (TRD).

At the Mensana Center, you receive this treatment in a calm, supportive environment where your comfort and safety are the top priority.

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Break free with SPRAVATO®

Spravato works differently from standard antidepressants, giving you another chance at healing.

Approved by the FDA

for treatment-resistant depression

Can relieve symptoms faster

than oral medications for many patients

Administered in-office

at the Mensana Center with continuous monitoring

How we support you through the process

Clear guidance

We explain eligibility, help with insurance requirements, and prepare you for what to expect before your first session.

Careful evaluation

We take time to understand your symptoms, history, and past treatments to determine whether SPRAVATO® may be a helpful option.

SPRAVATO® administration

Receive the medication at the Mensana Center, where our trained clinicians supervise the full session and monitor you closely for safety and comfort.

Steady follow-up

After each session, we check in, track your progress, and adjust your broader treatment plan so you feel supported throughout your care.

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You don’t need to worry

You might have heard about Spravato’s side effects. However, rest assured that they only occur during or shortly after treatment and fade the same day.

These may include:

Dizziness or nausea

Increased blood pressure

Tiredness afterward

Temporary perception changes

Slowed breathing

We review everything with you ahead of time so you feel prepared.

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Coverage information

Some insurance plans cover SPRAVATO® when specific criteria are met. If we find that you are eligible, we’ll help you understand your benefits and navigate the approval process.

Frequently Asked
Questions

about Spravato (esketamine)

What is SPRAVATO® (esketamine)?

SPRAVATO® (esketamine) CIII nasal spray is a derivative of ketamine.

What conditions is SPRAVATO® approved to treat?

SPRAVATO® is an FDA-approved nasal spray for treatment-resistant depression (TRD); it is also approved to treat depressive symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions.

What controlled substance schedule is SPRAVATO® classified under?

SPRAVATO® is a Schedule III controlled substance under the US Controlled Substances Act.

Where is SPRAVATO® administered?

SPRAVATO® is a nasal spray administered under clinical supervision at a designated treatment site. The Mensana Center is a designated SPRAVATO® treatment site.

Why is SPRAVATO® administered under supervision?

SPRAVATO® treatment is given under supervision because of its potential to cause temporary changes in perception, mood, or physical sensations. The goal is not to create a high but to help individuals find relief from symptoms of depression that have been resistant to other options.

Is SPRAVATO® used alone or with other medications?

SPRAVATO® is typically prescribed alongside an oral antidepressant.

How quickly does SPRAVATO® work?

Unlike standard medications that can take weeks to show results, SPRAVATO® may begin working more quickly, sometimes within hours or days. Speed varies from person to person.

How are vital signs monitored during treatment?

During SPRAVATO® treatment sessions, vital signs (blood pressure, pulse, respiratory rate, pulse oximetry) are measured before treatment, 40 minutes into the treatment session, and at 2 hours after treatment.

Who may not be a good candidate for SPRAVATO®?

SPRAVATO® may cause a temporary increase in blood pressure and heart rate and may not be suitable if a person has been diagnosed with uncontrolled high blood pressure, aneurysmal vascular disease, or a history of bleeding in the brain. Persons with cardiovascular risks will be carefully evaluated before the medication can be started.

How often will I need SPRAVATO® treatments?

When spravato is initiated, visits are twice weekly for 4 weeks and then weekly. Continued treatment is dependent on the patient's response to medication.

How long is a SPRAVATO® treatment visit?

On SPRAVATO® treatment days, individuals are observed at the Mensana Center for at least 2 hours after medication administration.

What is monitored during the 2-hour observation period?

During this time, the healthcare provider will monitor for:

Sedation (sleepiness or drowsiness)
Dissociation (feeling disconnected from oneself, thoughts, feelings, and surroundings)
Increased blood pressure (which typically peaks around 40 minutes post-dose and returns to normal within two hours)
Respiratory depression (slowed breathing)

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What medications should I avoid or discuss before taking SPRAVATO®?

It is crucial to inform your healthcare provider about all medications you take, including over-the-counter medicines, when taking SPRAVATO®:

Nasal decongestant or nasal corticosteroid: may be used before treatment. The person must wait at least one hour after using them before taking SPRAVATO®.
Antihistamines (e.g., diphenhydramine): can cause sedation and increase the side effects of SPRAVATO®, including drowsiness and impaired thinking. Antihistamines should not be used on days when taking SPRAVATO®.

What should I avoid eating or drinking before treatment?

Avoid eating for at least two hours and drinking liquids for at least 30 minutes before your SPRAVATO® treatment to minimize nausea.

How do people generally feel after SPRAVATO®?

SPRAVATO® is well-tolerated, and any discomfort typically decreases over time as patients adjust to the treatment. Many patients report feeling tired for a few hours after treatment; therefore, we recommend taking the rest of the day to rest and recuperate.

Can I drive after a SPRAVATO® session?

Persons receiving SPRAVATO® should not drive at all on the day of SPRAVATO® treatment. Recommendations include avoiding driving or operating machinery for the entire day after taking SPRAVATO®.

What items can patients bring to their treatment sessions?

Patients receiving SPRAVATO® are encouraged to bring in personal items for use during their treatment sessions. Recommendations include:

Wear comfortable clothing and bring a blanket, neck pillow, eye mask, and warm socks/slippers.
Items to use during treatment, such as headphones, a tablet, or a cell phone to listen to soothing music, guided meditations, and/or podcasts

You deserve to feel better.

If you’re exploring new options, we are here to help you do it with clarity and support.

Schedule a SPRAVATO® consultation